Serious Non-AIDS events: Immunopathogenesis and interventional strategies
نویسندگان
چکیده
منابع مشابه
Serious Non-AIDS events: Immunopathogenesis and interventional strategies
Despite the major advances in the management of HIV infection, HIV-infected patients still have greater morbidity and mortality than the general population. Serious non-AIDS events (SNAEs), including non-AIDS malignancies, cardiovascular events, renal and hepatic disease, bone disorders and neurocognitive impairment, have become the major causes of morbidity and mortality in the antiretroviral ...
متن کاملRisk of all-cause mortality associated with nonfatal AIDS and serious non-AIDS events among adults infected with HIV.
OBJECTIVES Among patients with HIV, the risk of death associated with different AIDS events has been quantified, but the risk of death associated with non-AIDS events has not been examined. We compared the risk of all-cause mortality following AIDS versus serious non-AIDS (SNA) events in the Strategies for Management of Antiretroviral Therapy (SMART) study and the Evaluation of Subcutaneous Pro...
متن کاملEmerging concepts in the immunopathogenesis of AIDS.
There is an intense interplay between HIV and the immune system, and the literature is replete with studies describing various immunological phenomena associated with HIV infection. Many of these phenomena seem too broad in scope to be attributable either to HIV-infected cells or to the HIV-specific immune response. Recently, a more fundamental understanding of how HIV affects various T cells a...
متن کاملAn idiotypic network model of AIDS immunopathogenesis.
Considerations from a network theory of the immune system suggest that human immunodeficiency virus and allogeneic stimuli may act synergistically to cause AIDS. The immune responses to these stimuli include two components that are directed against each other. In some AIDS risk groups other antigens that mimic major histocompatibility complex antigens may substitute for allogeneic stimuli. Impl...
متن کاملEffect of statin therapy in reducing the risk of serious non-AIDS-defining events and nonaccidental death.
BACKGROUND Excessive inflammation persists despite antiretroviral treatment. Statins decrease cardiovascular (CV) disease risk by reducing low-density lipoprotein cholesterol and inflammation. We performed an exploratory analysis to evaluate whether statin therapy decreased risk of non-AIDS-defining events and nonaccidental death. METHODS A total of 3601 subjects not on a statin from the AIDS...
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ژورنال
عنوان ژورنال: AIDS Research and Therapy
سال: 2013
ISSN: 1742-6405
DOI: 10.1186/1742-6405-10-29